Cell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex

Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1...

Full description

Saved in:
Bibliographic Details
Main Authors: Heuser, Michael, Yun, Haiyang, Berg, Tobias, Yung, Eric, Argiropoulos, Bob, Kuchenbauer, Florian, Park, Gyeongsin, Hamwi, Iyas, Palmqvist, Lars, Lai, Courteney K., Leung, Malina, Lin, Grace, Chaturvedi, Anuhar, Thakur, Basant Kumar, Iwasaki, Masayuki, Bilenky, Mikhail, Thiessen, Nina, Robertson, Gordon, Hirst, Martin, Kent, David, Wilson, Nicola K., Göttgens, Bertie, Eaves, Connie, Cleary, Michael L., Marra, Marco, Ganser, Arnold, Humphries, R. Keith
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951989/
https://ncbi.nlm.nih.gov/pubmed/21741595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.06.020
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items