Cell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex

Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1...

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Main Authors: Heuser, Michael, Yun, Haiyang, Berg, Tobias, Yung, Eric, Argiropoulos, Bob, Kuchenbauer, Florian, Park, Gyeongsin, Hamwi, Iyas, Palmqvist, Lars, Lai, Courteney K., Leung, Malina, Lin, Grace, Chaturvedi, Anuhar, Thakur, Basant Kumar, Iwasaki, Masayuki, Bilenky, Mikhail, Thiessen, Nina, Robertson, Gordon, Hirst, Martin, Kent, David, Wilson, Nicola K., Göttgens, Bertie, Eaves, Connie, Cleary, Michael L., Marra, Marco, Ganser, Arnold, Humphries, R. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951989/
https://ncbi.nlm.nih.gov/pubmed/21741595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.06.020
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