Initial Testing (Stage 1) of the Topoisomerase II inhibitor Pixantrone, by the Pediatric Preclinical Testing Program

Pixantrone, a novel aza-anthracenedione with cytotoxic activity, was tested against the PPTP in vitro panel (3.0 nM to 30.0 μM) and against a limited panel of PPTP Wilms tumors and sarcomas (7.5 mg/kg) administered intravenously using an every 4 day x 3 schedule. In vitro pixantrone showed a median...

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Autores principales: Kurmasheva, Raushan T., Reynolds, C. Patrick, Kang, Min H., Allievi, Cecilia, Houghton, Peter J., Smith, Malcolm A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951603/
https://ncbi.nlm.nih.gov/pubmed/24166988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24800
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