A temperature-sensitive mutant of human p53.

We discovered that the human 'hot-spot' p53 mutant 143Ala is temperature sensitive for the binding of two DNA elements and for mediating the transcription of a downstream luciferase reporter gene. At 32.5 degrees C, 143Ala possesses strong DNA binding ability. In addition, its transcriptional activi...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Zhang, W, Guo, X Y, Hu, G Y, Liu, W B, Shay, J W, Deisseroth, A B
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 1994
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8013454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06543.x
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