Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

Chemotherapeutic drugs are cytotoxic by induction of apoptosis in drug-sensitive cells. We investigated the mechanism of bleomycin-induced cytotoxicity in hepatoma cells. At concentrations present in the sera of patients during therapy, bleomycin induced transient accumulation of nuclear wild-type (...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Εκδόθηκε σε:	J Clin Invest
Κύριοι συγγραφείς:	Müller, M, Strand, S, Hug, H, Heinemann, E M, Walczak, H, Hofmann, W J, Stremmel, W, Krammer, P H, Galle, P R
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Clinical Investigation 1997
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507813/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9022073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119174
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