Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

Chemotherapeutic drugs are cytotoxic by induction of apoptosis in drug-sensitive cells. We investigated the mechanism of bleomycin-induced cytotoxicity in hepatoma cells. At concentrations present in the sera of patients during therapy, bleomycin induced transient accumulation of nuclear wild-type (...

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Bibliographische Detailangaben
Hauptverfasser: Müller, M, Strand, S, Hug, H, Heinemann, E M, Walczak, H, Hofmann, W J, Stremmel, W, Krammer, P H, Galle, P R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507813/
https://ncbi.nlm.nih.gov/pubmed/9022073
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