A temperature-sensitive mutant of human p53.

We discovered that the human 'hot-spot' p53 mutant 143Ala is temperature sensitive for the binding of two DNA elements and for mediating the transcription of a downstream luciferase reporter gene. At 32.5 degrees C, 143Ala possesses strong DNA binding ability. In addition, its transcriptio...

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Bibliografische gegevens
Hoofdauteurs: Zhang, W, Guo, X Y, Hu, G Y, Liu, W B, Shay, J W, Deisseroth, A B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1994
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC395127/
https://ncbi.nlm.nih.gov/pubmed/8013454
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