Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1. Development of a potent and CNS penetrant [3.1.0]-based lead

This letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach that provided a robust intellectual property position, in lieu of a traditional, expensive HTS campaign. Members within this new [3.1.0]-based series displayed excellent GlyT1...

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Hauptverfasser: Jones, Carrie K., Sheffler, Douglas J., Williams, Richard, Jadhav, Sataya B., Felts, Andrew S., Morrison, Ryan D., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951249/
https://ncbi.nlm.nih.gov/pubmed/24461352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.01.013
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