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Neurosteroid Analogues. 18. Structure–Activity Studies of ent-Steroid Potentiators of γ-Aminobutyric Acid type A Receptors and Comparison of Their Activities with Those of Alphaxalone and Allopregnanolone

A model of the alignment of neurosteroids and ent-neurosteroids at the same binding site on γ-aminobutyric acid type A (GABA(A)) receptors was evaluated for its ability to identify the structural features in ent-neurosteroids that enhance their activity as positive allosteric modulators of this rece...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Qian, Mingxing, Krishnan, Kathiresan, Kudova, Eva, Li, Ping, Manion, Brad D., Taylor, Amanda, Elias, George, Akk, Gustav, Evers, Alex S., Zorumski, Charles F., Mennerick, Steven, Covey, Douglas F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951241/
https://ncbi.nlm.nih.gov/pubmed/24328079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401577c
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