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Neurosteroid Analogues. 16. A new explanation for the lack of anesthetic effects of Δ(16)-alphaxalone and identification of a Δ(17(20)) analogue with potent anesthetic activity

This study addresses the hypothesis that the lack of anesthetic activity for (3α,5α)-3-hydroxypregn-16-ene-11,20-dione (Δ(16)-alphaxalone) is explained by the steroid Δ(16) double bond constraining the steroid 20-carbonyl group to a position that prevents it from favorably interacting with γ-aminobu...

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Detalhes bibliográficos
Main Authors: Stastna, Eva, Krishnan, Kathiresan, Manion, Brad D., Taylor, Amanda, Rath, Nigam P., Chen, Zi-Wei, Evers, Alex. S., Zorumski, Charles F., Mennerick, Steven, Covey, Douglas F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794474/
https://ncbi.nlm.nih.gov/pubmed/21504158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2002487
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