Pdx1 maintains β-cell identity and function by repressing an α-cell program

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic development and adult β-cell function. In this study, we traced the fate of adult β-cells after Pdx1 deletion. As expected, β-cell-specific removal of Pdx1 resulted in severe hyperglycemia within days. Surprisingl...

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Detalhes bibliográficos
Main Authors: Gao, Tao, McKenna, Brian, Li, Changhong, Reichert, Maximilian, Nguyen, James, Singh, Tarjinder, Yang, Chenghua, Pannikar, Archana, Doliba, Nicolai, Zhang, Tingting, Stoffers, Doris A., Edlund, Helena, Matschinsky, Franz, Stein, Roland, Stanger, Ben Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950964/
https://ncbi.nlm.nih.gov/pubmed/24506867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.12.002
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