Inhibition of cholinergic potentiation of insulin secretion from pancreatic islets by chronic elevation of glucose and fatty acids: Protection by casein kinase 2 inhibitor

OBJECTIVES: Chronic hyperlipidemia and hyperglycemia are characteristic features of type 2 diabetes (T2DM) that are thought to cause or contribute to β-cell dysfunction by “glucolipotoxicity.” Previously we have shown that acute treatment of pancreatic islets with fatty acids (FA) decreases acetylch...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Doliba, Nicolai M., Liu, Qin, Li, Changhong, Chen, Pan, Liu, Chengyang, Naji, Ali, Matschinsky, Franz M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641685/
https://ncbi.nlm.nih.gov/pubmed/29031723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.07.017
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