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Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets

Fatty acids, acetylcholine, and GLP-1 enhance insulin secretion in a glucose-dependent manner. However, the interplay between glucose, fatty acids, and the neuroendocrine regulators of insulin secretion is not well understood. Therefore, we studied the acute effects of PA (alone or in combination wi...

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Main Authors: Doliba, Nicolai M., Qin, Wei, Vinogradov, Sergei A., Wilson, David F., Matschinsky, Franz M.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944283/
https://ncbi.nlm.nih.gov/pubmed/20606076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00072.2010
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