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A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis
TNFα signaling can promote apoptosis or a regulated form of necrosis. ARC (apoptosis repressor with CARD (caspase recruitment domain)) is an endogenous inhibitor of apoptosis that antagonizes both the extrinsic (death receptor) and intrinsic (mitochondrial/ER) apoptosis pathways. We discovered that...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950326/ https://ncbi.nlm.nih.gov/pubmed/24440909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.195 |
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