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Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation
The central regulator of adipogenesis, PPARγ, is a nuclear receptor that is linked to obesity and metabolic diseases. Here we report that MKRN1 is an E3 ligase of PPARγ that induces its ubiquitination, followed by proteasome-dependent degradation. Furthermore, we identified two lysine sites at 184 a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950322/ https://ncbi.nlm.nih.gov/pubmed/24336050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.181 |
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