Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation

The central regulator of adipogenesis, PPARγ, is a nuclear receptor that is linked to obesity and metabolic diseases. Here we report that MKRN1 is an E3 ligase of PPARγ that induces its ubiquitination, followed by proteasome-dependent degradation. Furthermore, we identified two lysine sites at 184 a...

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Main Authors: Kim, J-H, Park, K W, Lee, E-W, Jang, W-S, Seo, J, Shin, S, Hwang, K-A, Song, J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950322/
https://ncbi.nlm.nih.gov/pubmed/24336050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.181
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