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Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D(3) receptors
BACKGROUND AND PURPOSE: In addition to typical GPCR kinase (GRK)-/β-arrestin-dependent internalization, dopamine D(3) receptor employed an additional GRK-independent sequestration pathway. In this study, we investigated the molecular mechanism of this novel sequestration pathway. EXPERIMENTAL APPROA...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Publishing Ltd
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949658/ https://ncbi.nlm.nih.gov/pubmed/23992580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12357 |
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