The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

Heterodimers of retinoid X receptor (RXR) and retinoic acid receptor (RAR) bind preferentially to directly repeated elements with spacing of two (DR2) or five (DR5) base pairs, due to the specific heterocooperative interaction of their DNA binding domains (DBDs) on these elements. We have demonstrat...

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Pubblicato in:	EMBO J
Autori principali:	Zechel, C, Shen, X Q, Chen, J Y, Chen, Z P, Chambon, P, Gronemeyer, H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394960/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8137826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06396.x
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