Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice

The preferential localization of some neoplasms, such as serrated polyps (SPs), in specific areas of the intestine suggests that nongenetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine but...

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Detalhes bibliográficos
Main Authors: Bongers, Gerold, Pacer, Michelle E., Geraldino, Thais H., Chen, Lili, He, Zhengxiang, Hashimoto, Daigo, Furtado, Glaucia C., Ochando, Jordi, Kelley, Kevin A., Clemente, Jose C., Merad, Miriam, van Bakel, Harm, Lira, Sergio A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949565/
https://ncbi.nlm.nih.gov/pubmed/24590763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131587
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