Recognition of the Thomsen-Friedenreich Pancarcinoma Carbohydrate Antigen by a Lamprey Variable Lymphocyte Receptor

Variable lymphocyte receptors (VLRs) are leucine-rich repeat proteins that mediate adaptive immunity in jawless vertebrates. VLRs were recently shown to recognize glycans, such as the tumor-associated Thomsen-Friedenreich antigen (TFα; Galβ1–3GalNAcα), with a selectivity rivaling or exceeding that o...

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Bibliografiska uppgifter
Huvudupphovsmän: Luo, Ming, Velikovsky, C. Alejandro, Yang, Xinbo, Siddiqui, Maqbool A., Hong, Xia, Barchi, Joseph J., Gildersleeve, Jeffrey C., Pancer, Zeev, Mariuzza, Roy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949333/
https://ncbi.nlm.nih.gov/pubmed/23782692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480467
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