Inhibition of Notch signaling reduces the number of surviving Dclk1(+) reserve crypt epithelial stem cells following radiation injury

We have previously reported that doublecortin-like kinase 1 (Dclk1) is a putative intestinal stem cell (ISC) marker. In this report, we evaluated the use of Dclk1 as a marker of surviving ISCs in response to treatment with high-dose total body irradiation (TBI). Both apoptotic and mitotic Dclk1(+) c...

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Detalhes bibliográficos
Main Authors: Qu, Dongfeng, May, Randal, Sureban, Sripathi M., Weygant, Nathaniel, Chandrakesan, Parthasarathy, Ali, Naushad, Li, Linheng, Barrett, Terrence, Houchen, Courtney W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Mucosal Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949020/
https://ncbi.nlm.nih.gov/pubmed/24368703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00088.2013
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