Acrolein, a ubiquitous pollutant and lipid hydroperoxide, inhibits antiviral activity of interferon-alpha: relevance to Hepatitis C

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and can lead to hepatocellular carcinoma and end-stage liver disease. The current FDA-approved treatment for HCV (pegylated interferon-alpha (IFNα) with ribavirin) is effective only in about 50% of patients. Epidemiological...

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Detalhes bibliográficos
Main Authors: Joshi-Barve, Swati, Amancherla, Kiranmayi, Patil, Madhuvanti, Bhatnagar, Aruni, Mathews, Stephanie, Gobejishvili, Leila, Cave, Matthew, McClain, Craig, Barve, Shirish
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947765/
https://ncbi.nlm.nih.gov/pubmed/19345260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.03.021
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