Mechanisms of Glucagon Degradation at Alkaline pH

Glucagon is unstable and undergoes degradation and aggregation in aqueous solution. For this reason, its use in portable pumps for closed loop management of diabetes is limited to very short periods. In this study, we sought to identify the degradation mechanisms and the bioactivity of specific degr...

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Main Authors: Caputo, Nicholas, Castle, Jessica R., Bergstrom, Colin P., Carroll, Julie M., Bakhtiani, Parkash A., Jackson, Melanie A., Roberts, Charles T., David, Larry L., Ward, W. Kenneth
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947653/
https://ncbi.nlm.nih.gov/pubmed/23651991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2013.04.005
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