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Mechanisms of Glucagon Degradation at Alkaline pH
Glucagon is unstable and undergoes degradation and aggregation in aqueous solution. For this reason, its use in portable pumps for closed loop management of diabetes is limited to very short periods. In this study, we sought to identify the degradation mechanisms and the bioactivity of specific degr...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947653/ https://ncbi.nlm.nih.gov/pubmed/23651991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2013.04.005 |
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