A Novel, Stable, Aqueous Glucagon Formulation Using Ferulic Acid as an Excipient

BACKGROUND: Commercial glucagon is unstable due to aggregation and degradation. In closed-loop studies, it must be reconstituted frequently. For use in a portable pump for 3 days, a more stable preparation is required. At alkaline pH, curcumin inhibited glucagon aggregation. However, curcumin is not...

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Pubblicato in:J Diabetes Sci Technol
Autori principali: Bakhtiani, Parkash A., Caputo, Nicholas, Castle, Jessica R., El Youssef, Joseph, Carroll, Julie M., David, Larry L., Roberts, Charles T., Ward, W. Kenneth
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2014
Soggetti:
Special Section: Glucagon Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495527/
https://ncbi.nlm.nih.gov/pubmed/25253164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1932296814552476
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