Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells

Colorectal cancer is ranked among the top leading causes of cancer death in industrialized populations. Polycomb group proteins (PcGs), including Suz12 and Ezh2, are epigenetic regulatory proteins that act as transcriptional repressors of many differentiation-associated genes and are overexpressed i...

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Autores principales: Benoit, Yannick D., Laursen, Kristian B., Witherspoon, Mavee S., Lipkin, Steven M., Gudas, Lorraine J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947628/
https://ncbi.nlm.nih.gov/pubmed/23001792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24224
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