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Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells

Colorectal cancer is ranked among the top leading causes of cancer death in industrialized populations. Polycomb group proteins (PcGs), including Suz12 and Ezh2, are epigenetic regulatory proteins that act as transcriptional repressors of many differentiation-associated genes and are overexpressed i...

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מידע ביבליוגרפי
Main Authors: Benoit, Yannick D., Laursen, Kristian B., Witherspoon, Mavee S., Lipkin, Steven M., Gudas, Lorraine J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947628/
https://ncbi.nlm.nih.gov/pubmed/23001792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24224
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