Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells

Colorectal cancer is among the leading causes of cancer death in the USA. The polycomb repressive complex 2 (PRC2), including core components SUZ12 and EZH2, represents a key epigenetic regulator of digestive epithelial cell physiology and was previously shown to promote deleterious effects in a num...

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Hauptverfasser: Benoit, Yannick D., Witherspoon, Mavee S., Laursen, Kristian B., Guezguez, Amel, Beauséjour, Marco, Beaulieu, Jean-Francois, Lipkin, Steven M., Gudas, Lorraine J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880229/
https://ncbi.nlm.nih.gov/pubmed/23588203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.04.006
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