Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

PURPOSE: A phase I, dose-finding study of vorinostat in combination with temozolomide (TMZ) was conducted to determine the maximum tolerated dose (MTD), safety, and pharmacokinetics in patients with high-grade glioma (HGG). EXPERIMENTAL DESIGN: This phase I, dose-finding, investigational study was c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lee, Eudocia Q., Puduvalli, Vinay K., Reid, Joel M., Kuhn, John G., Lamborn, Kathleen R., Cloughesy, Timothy F., Chang, Susan M., Drappatz, Jan, Yung, W. K. Alfred, Gilbert, Mark R., Robins, H. Ian, Lieberman, Frank S., Lassman, Andrew B., McGovern, Renee M., Xu, Jihong, Desideri, Serena, Ye, Xiabu, Ames, Matthew M., Espinoza-Delgado, Igor, Prados, Michael D., Wen, Patrick Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947570/
https://ncbi.nlm.nih.gov/pubmed/22923449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1841
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados