A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma

PURPOSE: To determine the maximum tolerated dose (MTD) of tipifarnib in combination with conventional radiotherapy (RT) for patients with newly diagnosed glioblastoma (GBM). MTD was evaluated in three patient cohorts, stratified based on concurrent use of enzyme inducing antiepileptic drugs (EIAED)...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Nghiemphu, Phioanh Leia, Wen, Patrick Y., Lamborn, Kathleen R., Drappatz, Jan, Robins, H. Ian, Fink, Karen, Malkin, Mark G., Lieberman, Frank S., DeAngelis, Lisa M., Torres-Trejo, Alejandro, Chang, Susan M., Abrey, Lauren, Fine, Howard A., Demopoulos, Alexis, Lassman, Andrew B., Kesari, Santosh, Mehta, Minesh P., Prados, Michael D., Cloughesy, Timothy F.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020272/
https://ncbi.nlm.nih.gov/pubmed/20934264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2010.07.1997
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