A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma

PURPOSE: To determine the maximum tolerated dose (MTD) of tipifarnib in combination with conventional radiotherapy (RT) for patients with newly diagnosed glioblastoma (GBM). MTD was evaluated in three patient cohorts, stratified based on concurrent use of enzyme inducing antiepileptic drugs (EIAED)...

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Autors principals: Nghiemphu, Phioanh Leia, Wen, Patrick Y., Lamborn, Kathleen R., Drappatz, Jan, Robins, H. Ian, Fink, Karen, Malkin, Mark G., Lieberman, Frank S., DeAngelis, Lisa M., Torres-Trejo, Alejandro, Chang, Susan M., Abrey, Lauren, Fine, Howard A., Demopoulos, Alexis, Lassman, Andrew B., Kesari, Santosh, Mehta, Minesh P., Prados, Michael D., Cloughesy, Timothy F.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020272/
https://ncbi.nlm.nih.gov/pubmed/20934264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2010.07.1997
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