Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03

PURPOSE: A phase I, dose-finding study of vorinostat in combination with temozolomide (TMZ) was conducted to determine the maximum tolerated dose (MTD), safety, and pharmacokinetics in patients with high-grade glioma (HGG). EXPERIMENTAL DESIGN: This phase I, dose-finding, investigational study was c...

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Autori principali: Lee, Eudocia Q., Puduvalli, Vinay K., Reid, Joel M., Kuhn, John G., Lamborn, Kathleen R., Cloughesy, Timothy F., Chang, Susan M., Drappatz, Jan, Yung, W. K. Alfred, Gilbert, Mark R., Robins, H. Ian, Lieberman, Frank S., Lassman, Andrew B., McGovern, Renee M., Xu, Jihong, Desideri, Serena, Ye, Xiabu, Ames, Matthew M., Espinoza-Delgado, Igor, Prados, Michael D., Wen, Patrick Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947570/
https://ncbi.nlm.nih.gov/pubmed/22923449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1841
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