Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma

PURPOSE: Inhibitors of the DNA damage response (DDR) have great potential for radiosensitization of numerous cancers including glioblastomas (GBM), which are extremely radio- and chemo-resistant brain tumors. Currently, there are no DNA double-strand break (DSB) repair inhibitors that have been succ...

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Hauptverfasser: del Alcazar, Carlos Rodrigo Gil, Gillam, Molly Catherine, Mukherjee, Bipasha, Tomimatsu, Nozomi, Gao, Xiaohuan, Yan, Jingsheng, Xie, Xian-Jin, Bachoo, Robert, Li, Li, Habib, Amyn A., Burma, Sandeep
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947495/
https://ncbi.nlm.nih.gov/pubmed/24366691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1607
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