The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

Inhibitors of PI3K/Akt signaling are being actively developed for tumor therapy owing to the frequent mutational activation of the PI3K-Akt-mTORC1 pathway in many cancers, including glioblastomas (GBMs). NVP-BEZ235 is a novel and potent dual PI3K/mTOR inhibitor that is currently in phase 1/2 clinica...

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Hauptverfasser: Mukherjee, Bipasha, Tomimatsu, Nozomi, Amancherla, Kaushik, Camacho, Cristel V, Pichamoorthy, Nandini, Burma, Sandeep
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281940/
https://ncbi.nlm.nih.gov/pubmed/22355272
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