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Novel Histone Deacetylase Inhibitors with Enhanced Enzymatic Inhibition Effects and Potent in vitro and in vivo Anti-tumor Activities
In the present work, a series of small molecules were designed and synthesized based on structural optimization. Significant improvement in the enzymatic inhibition activity of the synthesized compounds was discovered. Moreover, tested compounds have moderate preference for class I HDACs over HDAC6...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947464/ https://ncbi.nlm.nih.gov/pubmed/24227760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300297 |
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