Polycomb repressive complex 2 regulates hematopoietic stem cell maintenance and differentiation in a developmental stage-specific manner

Recent studies point to a pivotal role of polycomb repressive complex 2 (PRC2) in stem cell function and cancer. Loss of function approaches targeting individual PRC2 subunits have however generated findings that are difficult to reconcile. Here, we prevent assembly of both Ezh1- and Ezh2-containing...

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Hlavní autoři: Xie, Huafeng, Xu, Jian, Hsu, Jessie H., Nguyen, Minh, Fujiwara, Yuko, Peng, Cong, Orkin, Stuart H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947409/
https://ncbi.nlm.nih.gov/pubmed/24239285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.10.001
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