Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment

Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T cells, the molecular mechanisms that orchestrate TEC development from endodermal progenitors in the third pharyngeal pouch (3(rd) PP) are no...

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Udgivet i:Sci Rep
Main Authors: Singarapu, Nandini, Ma, Keyue, Reeh, Kaitlin A. G., Shen, Jianjun, Lancaster, Jessica N., Yi, Song, Xie, Huafeng, Orkin, Stuart H., Manley, Nancy R., Ehrlich, Lauren I. R., Jiang, Ning, Richie, Ellen R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156232/
https://ncbi.nlm.nih.gov/pubmed/30254371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32729-z
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