Inhibition of CSF1 Receptor Improves the Anti-tumor Efficacy of Adoptive Cell Transfer Immunotherapy

Colony stimulating factor-1 (CSF-1) recruits tumor-infiltrating myeloid cells (TIMs) that suppress tumor immunity, including M2 macrophages and myeloid derived suppressor cells (MDSC). The CSF-1 receptor (CSF-1R) is a tyrosine kinase that is targetable by small molecule inhibitors such as PLX3397. I...

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Bibliografski detalji
Glavni autori: Mok, Stephen, Koya, Richard C., Tsui, Christopher, Xu, Jingying, Robert, Lídia, Wu, Lily, Graeber, Thomas, West, Brian L., Bollag, Gideon, Ribas, Antoni
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947337/
https://ncbi.nlm.nih.gov/pubmed/24247719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1816
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