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Differentiation between low- and high-efficacy CB(1) receptor agonists using a drug discrimination protocol for rats

RATIONALE: The “subjective high” from marijuana ingestion is likely due to Δ(9)-tetrahydrocannabinol (THC) activating the central cannabinoid receptor type 1 (CB(1)R) of the endocannabinoid signaling system. THC is a weak partial agonist according to in vitro assays, yet THC mimics the behavioral ef...

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Detalhes bibliográficos
Main Authors: Järbe, Torbjörn U. C., LeMay, Brian J., Halikhedkar, Aneetha, Wood, JodiAnne, Vadivel, Subramanian K., Zvonok, Alexander, Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947118/
https://ncbi.nlm.nih.gov/pubmed/24005529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-013-3257-8
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