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Differentiation between low- and high-efficacy CB(1) receptor agonists using a drug discrimination protocol for rats
RATIONALE: The “subjective high” from marijuana ingestion is likely due to Δ(9)-tetrahydrocannabinol (THC) activating the central cannabinoid receptor type 1 (CB(1)R) of the endocannabinoid signaling system. THC is a weak partial agonist according to in vitro assays, yet THC mimics the behavioral ef...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947118/ https://ncbi.nlm.nih.gov/pubmed/24005529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-013-3257-8 |
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