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STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

Myeloid leukemia M1 cells can be induced for growth arrest and terminal differentiation into macrophages in response to interleukin 6 (IL-6) or leukemia inhibitory factor (LIF). Recently, a large number of cytokines and growth factors have been shown to activate the Janus kinase (JAK)-signal transdu...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Minami, M, Inoue, M, Wei, S, Takeda, K, Matsumoto, M, Kishimoto, T, Akira, S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39468/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8632998/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.3963
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