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A Bayesian Adaptive Phase I-II Clinical Trial for Evaluating Efficacy and Toxicity with Delayed Outcomes
BACKGROUND: In traditional phase I oncology trials, the safety of a new chemotherapeutic agent is tested in a dose escalation study to identify the maximum tolerated dose, which is defined as the highest dose with acceptable toxicity. An alternate approach is to jointly model toxicity and efficacy a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946437/ https://ncbi.nlm.nih.gov/pubmed/24082004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774513500589 |
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