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A Synthesis of the Tetracyclic Core of Exiguaquinol

[Image: see text] A Diels–Alder reaction, a desymmetrizing aldol reaction, and a reductive Heck cyclization are employed in a short synthesis of a tetracycle relevant to exiguaquinol, a potential antibiotic. Ground-state energies of this advanced model system and the natural product rationalize the...

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Bibliographic Details
Main Authors: Schwarzwalder, Gregg M., Steinhardt, Sarah E., Pham, Hung V., Houk, K. N., Vanderwal, Christopher D.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946388/
https://ncbi.nlm.nih.gov/pubmed/24219829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol402905n
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