Crystal Structure of the Vaccinia Virus DNA Polymerase Holoenzyme Subunit D4 in Complex with the A20 N-Terminal Domain

Vaccinia virus polymerase holoenzyme is composed of the DNA polymerase E9, the uracil-DNA glycosylase D4 and A20, a protein with no known enzymatic activity. The D4/A20 heterodimer is the DNA polymerase co-factor whose function is essential for processive DNA synthesis. Genetic and biochemical data...

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Hauptverfasser: Contesto-Richefeu, Céline, Tarbouriech, Nicolas, Brazzolotto, Xavier, Betzi, Stéphane, Morelli, Xavier, Burmeister, Wim P., Iseni, Frédéric
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946371/
https://ncbi.nlm.nih.gov/pubmed/24603707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003978
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