Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis

Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial proteins whose accumulation is deleterious to bacterial growth and survival. To...

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Main Authors: Raju, Ravikiran M., Jedrychowski, Mark P., Wei, Jun-Rong, Pinkham, Jessica T., Park, Annie S., O'Brien, Kathryn, Rehren, German, Schnappinger, Dirk, Gygi, Steven P., Rubin, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946367/
https://ncbi.nlm.nih.gov/pubmed/24603869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003994
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