Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

Protein alkylation by reactive electrophiles contributes to chemical toxicities and oxidative stress, but the functional impact of alkylation damage across proteomes is poorly understood. We used Click chemistry and shotgun proteomics to profile the accumulation of proteome damage in human cells tre...

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Detalhes bibliográficos
Main Authors: Codreanu, Simona G., Ullery, Jody C., Zhu, Jing, Tallman, Keri A., Beavers, William N., Porter, Ned A., Marnett, Lawrence J., Zhang, Bing, Liebler, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945913/
https://ncbi.nlm.nih.gov/pubmed/24429493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.032953
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