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Quantitative Chemoproteomics for Site-Specific Analysis of Protein Alkylation by 4-Hydroxy-2-Nonenal in Cells

[Image: see text] Protein alkylation by 4-hydroxy-2-nonenal (HNE), an endogenous lipid derived electrophile, contributes to stress signaling and cellular toxicity. Although previous work has identified protein targets for HNE alkylation, the sequence specificity of alkylation and dynamics in a cellu...

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Detalles Bibliográficos
Publicado en:Anal Chem
Main Authors: Yang, Jing, Tallman, Keri A., Porter, Ned A., Liebler, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350606/
https://ncbi.nlm.nih.gov/pubmed/25654326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac504685y
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