Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope: IMPLICATIONS FOR ANTIBODY RECOGNITION MECHANISM AND IMMUNOGEN DESIGN

The membrane-proximal external region (MPER) of gp41 harbors the epitope recognized by the broadly neutralizing anti-HIV 2F5 antibody, a research focus in HIV-1 vaccine development. In this work, we analyze the structure and immunogenic properties of MPERp, a peptide vaccine that includes the follow...

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Bibliographische Detailangaben
Hauptverfasser: Serrano, Soraya, Araujo, Aitziber, Apellániz, Beatriz, Bryson, Steve, Carravilla, Pablo, de la Arada, Igor, Huarte, Nerea, Rujas, Edurne, Pai, Emil F., Arrondo, José L. R., Domene, Carmen, Jiménez, María Angeles, Nieva, José L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945320/
https://ncbi.nlm.nih.gov/pubmed/24429284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527747
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