Membrane-Proximal External HIV-1 gp41 Motif Adapted for Destabilizing the Highly Rigid Viral Envelope

Electron microscopy structural determinations suggest that the membrane-proximal external region (MPER) of glycoprotein 41 (gp41) may associate with the HIV-1 membrane interface. It is further proposed that MPER-induced disruption and/or deformation of the lipid bilayer ensue during viral fusion. Ho...

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Main Authors: Apellániz, Beatriz, Ivankin, Andrey, Nir, Shlomo, Gidalevitz, David, Nieva, José L.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2011
Assuntos:
Membrane
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218338/
https://ncbi.nlm.nih.gov/pubmed/22098741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.005
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