The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

The use of opioid agonists acting outside the central nervous system (CNS) is a promising therapeutic strategy for pain control that avoids deleterious central side effects such as apnea and addiction. In human clinical trials and rat models of inflammatory pain, peripherally restricted opioids have...

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Detalhes bibliográficos
Main Authors: Nockemann, Dinah, Rouault, Morgane, Labuz, Dominika, Hublitz, Philip, McKnelly, Kate, Reis, Fernanda C, Stein, Christoph, Heppenstall, Paul A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944465/
https://ncbi.nlm.nih.gov/pubmed/23818182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201980
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