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The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia
The use of opioid agonists acting outside the central nervous system (CNS) is a promising therapeutic strategy for pain control that avoids deleterious central side effects such as apnea and addiction. In human clinical trials and rat models of inflammatory pain, peripherally restricted opioids have...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Science Inc
2013
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944465/ https://ncbi.nlm.nih.gov/pubmed/23818182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201980 |
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