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Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents
Slow response to the standard treatment for depression increases suffering and risk of suicide. Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, can rapidly alleviate depressive symptoms and reduce suicidality, possibly by decreasing hyperactivity in the lateral habenula (LHb) brain nuc...
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| 發表在: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7007545/ https://ncbi.nlm.nih.gov/pubmed/31941713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916570117 |
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