Adeno-associated Virus–mediated Delivery of a Recombinant Single-chain Antibody Against Misfolded Superoxide Dismutase for Treatment of Amyotrophic Lateral Sclerosis

There is emerging evidence that the misfolding of superoxide dismutase 1 (SOD1) may represent a common pathogenic event in both familial and sporadic amyotrophic lateral sclerosis (ALS). To reduce the burden of misfolded SOD1 species in the nervous system, we have tested a novel therapeutic approach...

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Библиографические подробности
Главные авторы: Patel, Priyanka, Kriz, Jasna, Gravel, Mathieu, Soucy, Geneviève, Bareil, Christine, Gravel, Claude, Julien, Jean-Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944333/
https://ncbi.nlm.nih.gov/pubmed/24394188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.239
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